July 7, 2024
Session 1: Inflammatory and Immune Signaling I
These presenters have opted out of being recorded:
- Keynote Presentation: Combinatorial and temporal signaling codes to specify innate immune responses, Alexander Hoffmann.
- Prediction and perturbation of signaling events directing cytokine specificity, Rachel Gottschalk.
- Pulsatile stimulation can minimize exhaustion in CAR-T cell signaling, John James.
- Leveraging time-varying microenvironments and dual reporter cells to reveal dynamic encoding properties of the IKK-NF-kB signaling axis, Robin Lee.
July 8, 2024
Session 2: Quantitative Models of Signaling Dynamics
These presenters have opted out of being recorded:
- Sculpturing organisms via waves of cell death. Sheng-Hong Chen.
- Fisher Information Based Design of Single-Cell Experiments to Infer Predictive Models of Signal-Activated Gene Expression, Brian Munsky.
- How do hormone oscillations encode metabolic responses? Mark Greenwood.
- Connecting Live-cell ERK Activity Dynamics to Fixed-Cell Effector Protein Expression, Abhineet Ram.
- From clocks to dominoes: modulating cell cycle tempo during cellular differentiation, Silvia Santos.
- Understanding the language of immunity through NF-κB signaling, Myong-Hee "Mia" Sung.
Session 3: Inflammatory and Immune Signaling II
- Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination, Harish Venkatachalapathy.
- Multisite phosphorylation of Chk2 influence the p53 response to sustained damage, Theresa Ingenhaag.
These presenters have opted out of being recorded:
- Long-term single-cell quantification: new tools for old questions, Timm Schroeder.
- Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity, Jennifer Oyler-Yaniv.
- Regulation of virulence gene expression during environmental transitions, Keara Lane.
July 9, 2024
Session 4: Imaging and Computational Innovations
- Deep learning-enabled integrated measurements of immune signaling in primary human macrophages, Emily Laubscher.
- Multi-channel time series classification and extrinsic regression uncovers biologically-significant patterns for fate determination from single-cell transcription factor data, Woody March-Steinman.
- Engineering longevity – computationally-guided reprogramming of cell aging, Nan Hao.
These presenters have opted out of being recorded:
- Molecular profiling of cell decisions using predictive single-cell dynamics, Jeremie Roux.
- Signal encoding and decoding in generation and function of blood vessels, Andre Levchenko.
- Spatial coordination and mechanical coupling: embryonic growth and patterning in synthetic systems, Qiong Yang.
- TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging, Blythe Hospelhorn.
Session 5: Biosensor and Optogenetic Tool Development
- Sensing and controlling receptor tyrosine kinase signaling, Jared Toettcher.
- De novo design of binders to cell signaling mediators for spatiotemporal control of cell signaling, Hojun Choi.
- Widespread modulation of transmembrane RTK signaling by diverse oncogenic RTK fusion condensates, Carol Gao.
- Examining the spatiotemporal cascade, Gary Mo.
This presenter has opted out of being recorded:
- Illuminating the Biochemical Activity Architecture of the Cell, Jin Zhang.
July 10, 2024
Session 6: In Vivo, Developmental, and Spatial Signaling Dynamics
- Dynamic live-cell tissue models reveal spatiotemporal drivers of signaling and gene expression heterogeneity in the metastatic niche, Alex Davies.
- Linking biological rhythms and metabolic disease, Mary Teruel.
These presenters have opted out of being recorded:
- Understanding the emergence of microbial collective behaviors: working toward linking signaling to behaviors, Allyson Sgro.
- Self-organization of MAPK signaling in epithelial homeostasis and developmental patterning, Olivier Pertz.
- GPCR trafficking sculpts receptor-specific cyclic AMP signal transduction, Emily Blythe.
- Deciphering the cellular integration of contradictory BMP and TGFβ signals, Yaron Antebi.
Session 7: Regulation of Gene Expression and Cell State
- Coordination of protein synthesis and decay in mammalian cells, David Suter.
- Multi-scale p53 dynamics: from single molecules to expression levels (and back), Davide Mazza.
- Decoding YAP dynamics through transcriptional condensates, Kirstin Meyer.
These presenters have opted out of being recorded:
- Differential regulation of transcriptional programs in response to dynamic patterns of JNK activation, Abbas Jedariforoughi.
- Transcription factor localization dynamics and DNA binding drive distinct promoter interpretations, Megan McClean.
- Multimodal perception links cellular state to decision-making in single cells, Serguei Ovinnikov.
July 11, 2024
Session 8: Cellular Homeostasis and Internal Cell States
- Endoplasmic reticulum–plasma membrane contact gradients direct cell migration, Tobias Meyer.
- Suicide signaling and death decisions in apoptosis, Markus Morrison.
- Circadian Coupling Orchestrates Cell Growth, Adrian E. Granada.
- Signaling and Cell Cycle Dynamics in Response to Ribosome Collisions, Sergi Regot.
These presenters have opted out of being recorded:
- Illuminating compartmentalized AMPK activity in single cells, Danielle Schmitt.
- mTOR-mediated transient APC/C inactivation is required for mammalian cell cycle entry, Debasish Paul.
- Exploring the impact of the TOR pathway on cellular commitment to division across environmental conditions, María Florencia Guerra.
Session 9: Signaling Dynamics in Cancer
- Searching for Single-Cell Predictors of Stochastic Division and Death Fates, Marc Birtwistle.
- Oncogenic Kras mutation converts pulsatile into sustained ERK activation to disrupt epithelial tissue architecture in the mouse skin, Tianchi Xin.
- Dynamic control of synthetic and native cell behaviors using thermal stimuli, Lukasz Bugaj.
These presenters have opted out of being recorded:
- Keynote: p53 Dynamics and Decision Making in Single Cells, Galit Lahav.
- Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping, Carolin Ector.
