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10.1096/ERCF2023
Endoplasmic Reticulum (ER): Structure, Function and Disease -2023 (Conferences On-Demand)
June 11, 2023 - June 15, 2023
Launched in 2007, this cross-disciplinary FASEB Science Research Conference (SRC) is focused on endoplasmic reticulum (ER) function and dynamics, and the contribution of ER dysfunction to disease. The conference brings together cell biologists and disease-oriented researchers, including both trainees and independent investigators. It attracts basic researchers interested in protein folding, protein secretion, cellular stress responses, protein post-translational modification, proteasome dependent protein degradation, and regulation of lipid biosynthesis, as well as researchers focusing on a range of pathologies, including diabetes, neurodegeneration, cancer, and diseases of protein misfolding.
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June 11, 2023
Keynote Lecture: Mechanisms of Mitochondria-ER Dynamics, Jodi Nunnari
June 12, 2023
Session 1: Early Events in ER Protein Biogenesis
- Mechanism of Sec61 Translocation Inhibition by Small Molecules, Eunyong Park
- A Universal Mechanism for the Catalytic Cycle of Get3, Bil Clemons
- Loss of GRP170 Results in Catastrophic Disruption of ER Function, Linda Hendershot
- Coordinating ER Structure and Function Across an Organism to Promote Longevity, Andrew Dillin
Session 2: ER Organelle Contact and Communication
- Freezing or Melting Mitochondria-ER Contacts (MERCs), Thomas Simmen
- Interrogating Lipid Droplet-Organelle Interaction Using a Generalizable Tool Kit, Chi-Lun Chang
- Role of a S-acylation of Proteins in the Secretory Pathway: Focus on CLIMP-63, Gisou van der Goot
- uL24/RPL26 UFMylation Is Essential for Ribosome Quality Control at the ER, Francesco Scavone
- Membrane-Embedded RNF26 Binds Perinuclear Vimentin Filaments to Integrate ER and Endolysosomal Responses to Preteotoxic Stress, IIana Berlin
June 13, 2023
Session 3: ER Protein Misfolding and Turnover
- Decisions Underlying the Quality Control of Proteins Via the ERAD and Post-ER Degradation Pathways, Jeff Brodsky
- Z-⍺-1-antitrypsin Polymers Impose Molecular Filtration in the Endoplasmic Reticulum After Undergoing Phase Transition to a Solid State, Stefan Marciniak
- The ER-Associated SKN-1A/Nrf1 Transcription Factor Links ERAD to Cytosolic Protein Turnover, Nicholas Lehrbach
- Mechanisms of Protein Import into Peroxisomes, Tom Rapoport
Session 4: Lipid Dynamics and Storage
- Mechanisms of ER Neutral Lipid Flux and Lipid Storage, James Olzmann
- A Proposed Role for Protein-Mediated Bulk Lipid Transfer in Membrane Expansion and Organelle Biogenesis, Karin Reinisch
- New Pathways for Metabolic Organization at Organelle Contact Sites, Hanaa Hariri
- Short Talk 3: Growing Fat: Real-Time Visualization of Lipid Droplet Biogenesis Using Model Membranes, Raunaq Deo
- Short Talk 4: Dissecting the Synergistic Role of Unfolded Protein Response in Wound Infections, Stella Lee
June 14, 2023
Session 5: ER Dynamics
- A Molecular Iron Shapes Rough ER Sheets, Gia Voeltz
- Regulation of Lipid Metabolism from the Nuclear Envelope, Shirin Bahmanyar
- ER Remodeling Via Ubiquitin and Autophagy Pathways, Ivan Dikic
- ER Organization in Neuronal Polarity, Ginny Farias
- Short Talk 5: ER Dysmorphia Underlies CD8+TIL Dysfunction in Solid Cancers
Session 6: ER Remodeling and Turnover
- Control of ER Homeostasis by ER-phagy Programs, Maurizio Molinari
- ER Structure and Function in Metabolic Regulation, Ana Paula Arruda
- Short Talk 6: A Selectivity Filter in the EMC Limits Protein Misinsertion at the ER, Tino Pleiner
- The Contribution of ERAD to ER Stress Resolution, John Christianson
- Short Talk 7: The ER Membrane Protein Complex (EMC) Governs Endolysosmal Turnover of Mitochondrial Tail-Anchored Protein, BNIP3, to Restrict Mitophagy, Chris Shoemaker
- Short Talk 8: Stress Granules Protect ER-Exit Sites from TDP43 Aggregation, Hongyi Wu
June 15, 2023
Session 7: Responding to ER Stress
- New and Unexpected Connections of the Plant ER, Federica Brandizzi
- How Stress and Immunity Intertwine to Regulate Vector Competence of Ticks, Dana Shaw
- Impact of ER Stress to the Nuclear Structure Function (or ER Cell Cycle Checkpoint for Ensuring Functional ER Inheritance), Maho Niwa
- An ERAD-Independent Role for Rhomboid-Like Derlin in Mediating Sphingolipid Homeostasis, Sonya Neal
- Short Talk 9: Co-Translational mRNA Surveillance by the ER Stress Sensor, IRE-1, Smriti Sangwan
- Short Talk 10: A New Role for the p24 Family in Antitrypsin Z Clearance from the Endoplasmic Reticulum, Prasanna Satpute-Krishnan
Session 8: The ER, Aging, and Disease
- Activation of the UPR by Olfactory Cues Can Delay Organismal Aging, Rebecca Taylor
- Deciphering the Role of Beta Cell ER Stress in Autoimmune Diabetes Pathogenesis, Feyza Engin
- How ER Stress Pathways Affect the Trafficking and Degradation of Protein Aggregates, Julie Hollien
- Regulation of IRE1b Function in Intestinal Goblet Cells, Sophie Janssens
- Short Talk 11: The ER Stress Transducer ATF6 Promotes Fatty Liver Disease-Driven Cancer, Cynthia Lebeaupin
- Short Talk 12: A Motor Neuron Disease-Associated Mutation Produces Non-Glycosylated Seipin that Induces ER Stress and Apoptosis by Inactivating SERCA2b, Shunske Saito
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Carolyn Sevier, PhD: Associate Professor, Molecular Medicine at Cornell University
Guillaume Thibault, PhD: Associate Professor, Nanyang Technological University
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Chair: Carolyn Sevier
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Session Chair: Tom Rapoport
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A Universal Mechanism for the Catalytic Cycle of Get3
March 04, 2024
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Chair: Andrew Dillin
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Chair: Maho Niwa
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Mechanisms of Protein Import into Peroxisomes
March 04, 2024
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Chair: Maurizio Molinari
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Chair: Linda Hendershot
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A Molecular Iron Shapes Rough ER Sheets
March 04, 2024 -
ER Remodeling Via Ubiquitin and Autophagy Pathways
March 04, 2024 -
ER Organization in Neuronal Polarity
March 04, 2024
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Chair: Gia Voeltz
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Control of ER Homeostasis by ER-Phagy Programs
March 04, 2024
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Chair: James Olzmann
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New and Unexpected Connections of the Plant ER
March 04, 2024
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Chair: Guillaume Thibault
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