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10.1096/HM2023
Hematologic Malignancies - 2023 (Conferences On-Demand)
August 06, 2023 - August 11, 2023
Launched in 1995, this FASEB Science Research Conference (SRC) is focused on all aspects of the biology of hematological malignancies including molecular pathogenesis of blood cancers, control of stem cell function and differentiation, chromatin biology, and new therapeutic strategies. This conference brings together principal investigators and trainees studying the molecular pathogenesis of cancers of the blood. It aims to encourage knowledge exchange and interdisciplinary collaborations as well as foster networking and career development opportunities for junior investigators and trainees.
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August 6, 2023
Keynote Lecture: Mechanisms Driving Clonal Hematopoiesis, Margaret Goodell This video is not included in the FASEB Conferences On-Demand product.
August 7, 2023
Session 1
- Proto-Oncogenes and the Lymphomyeloid Bridge in Normal T-Cell Development, Ellen Rothenberg
- ROS and TLR Signaling Balance “Eat Me” and “Don’t Eat Me” Signals to Determine Stem and Cell Clonal Selection by Macrophages, Cecilia Pessoa Rodrigues
- Acquired Non-Coding Mutations Retarget Super-Enhancer Activity During B-Cell Lymphoma Progression, Uttiya Basu
- Control of Ribosomal RNA Transcription by Hematopoietic Transcription Factors, Vikram Paralkar
- Therapeutic Targeting of SF3B1-Mutant Stem Cells, Sergei Doulatov
- Genome-wide Transcription Factor Binding Maps Reveal Cell-Specific Changes in the Regulatory Architecture of Human HSPCs, Julie Thoms
- ETV6 and ERG: Two PNT Domain ETS Transcription Factors– Contrasting Roles in Leukemogenesis, Shai Izraeli
Session 2
- Targeting Aberrant Gene Control in Leukemias, Alex Kentsis
- Targeting BcI-XL in Leukemias, Marina Konopleva
- Polyamines are required for AML LSC Function Through Their Role in Regulating eIF5A, Vincent Rondeau [Date/Time]
- Hypermutation of Super-Enhancer Networks in Diffuse Large B Cell Lymphoma, Laura Pasqualucci This video is not included in the FASEB Conferences On-Demand product.
- DYRK1A Regulates Alternative Splicing in B-ALL, John Crispino
August 8, 2023
Session 3
- RNA Regulators Control Cell Fate, Michael Kharas
- Enhanced Efficacy of Combinatorial Epigenetic Therapies in Diffuse Large B-Cell Lymphoma, Pilar Dominguez
- Niche Driven Inflammatory Regulation in the Pathogenesis and Treatment of Myeloid Malignancies, Stavroula Kousteni This video is not included in the FASEB Conferences On-Demand product.
- Targeting Epigenetic Resistance Mechanisms to PI3 Kinase Inhibition in Leukemic Stem Cells, Shira Glushakow-Smith
- Stem Cells in Human AML, Ravindra Majeti
- The XPO7/NPAT Axis as a Potential Therapeutic Target for TP53-Mutated AML, Takahiro Maeda
Session 4
- KMT2A-Rearranged Leukemias: Updates and Opportunities, Irmela Jeremias
- Novel Innate Immune Signaling Targets and Strategies for Suppressing MDS/AML LSPCs, Daniel Starczynowski
- GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic Cell Population Sustained by the Fetal Liver, but Not Bone Marrow, Paresh Vyas
- There and Back Again: Ultraviolet Radiation Shapes Leukemia Evolution in the Skin, Andrew Lane
- Semaphorin 4A Mediates Inflammation Resistance of Myeloid-Biased HSC, Lev Silberstein
August 9, 2023
Session 5
- Pre-leukemic Loss of Tet2 Perturbs Emergency Myelopoiesis Pathway Activation, Emmanuelle Passegue
- Heme Is a Master Regulator of Gene Expression, Metabolism and Drug Sensitivity in Acute Myeloid Leukemia, Lev Kats
- Growth Control, Stemness, Plasticity and Immunogenicity: The Multiple Faces of (Post-)Senescence in Hamatologic Malignancies, Clemens Schmitt
- Acetyl Transferase EP300 Deficiency Leads to Chronic Replication Stress, Mediated by Defective Fork Protection at Stalled Replication Forks in Adult T-Cell Leukemia/Lymphoma, Advaitha Madireddy
- Probing for Mechanisms of Immune Evasion in Myeloid Neoplasms, Iannis Aifantis
- Targeting the Oncofetal Transcription Factor Protein SALL4 in Cancer by a Non-IMID Degrader, Li Chai
- Deciphering an Altered HSC-Megakaryocyte Differentiation Trajectory in Calr/Asxl1 Co-mutant Mice, Ann Mullally
Session 6
- Emerging AML Dependencies from Functional Genomic Screens, Kimberly Stegmaier
- STAG2-Mutant MDS Development Is Associated with Accumulation of R-Loops, Zuzana Tothova
- Evil Enhancers in AML, Ruud Delwel
- Stag2-Cohesin Loss Pertubes Npm1c and Flt3ITD Mutant Hematopoietic Stem and Progenitor Differentiation, Jane Xu
- Chromatin Factors and Differential Gene Regulatory Complexes in Normal and Malignant Haematopoiesis, Brian Huntly
- Mechanisms of Lineage Plasticity in Response to Therapy in AML, Andrew Volk
August 10, 2023
Session 7
- Regulation of Dormant Hematopoietic Stem Cells in Disease, Nina Cabezas-Wallscheid This video is not included in the FASEB Conferences On-Demand product.
- Kinase Dead BTK Mutations Confer Resistance to Covalent and Non-Covalent BTK Inhibitors, But Are Susceptible to Clinical Stage BTK Degrader NX-2127, Justin Taylor
- Cellular Barcoding Reveals That the Adult Hematopoietic Stem Cell Niche Is Clonaly and Transcriptionally Remodeled by Acute Leukemia, Chloe Baron
- The Chromatin Reader SGF29 Is a Novel and Highly Selective Vulnerability in AML, Karina Barbosa
- Epigenetic Basis and Therapy of DLBCL, Ari Melnick
- N/KRAS-mutant AML LSCs Are Resistant to Venetoclax and Drive Clinical Responses, Eirini Papapetrou
- Vivo Crispr Screen Identifies Metabolic Vulnerabilities of Leukemia That Spreads to the Central Nervous System, Naama Kanarek
August 11, 2023
Session 8
- Therapeutic Targeting of Acute Leukemia with Upregulated HOX Genes, Jolanta Grembecka
- Btg2 Regulates Myc mRNA Stability and Leukemia-Initiating Cell Dormancy in T-ALL, Kelsey Wagner
- Native Stem Cell Transcriptional Circuits Define Cardinal Features of High-Risk Early T-Cell Precursor Acute Lymphoblastic Leukemia, Mark Chiang
- Therapeutic Targeting of ACLY in T-ALL in Vivo, Victoria Da Silva Diz
- Understanding and Targeting Transcription Dynamics in Normal and Malignant Hematopoiesis, Ulrich Steidl
- Targeting Venetoclax-Resistant Acute Myeloid Leukemia Stem Cell, Scott Armstrong
- Closing Keynote Lecture: Understanding the Cell-Intrinsic and Microenvironmental Influences on Cell Fate and Output of Hematopoietic Stem and Progenitor Cells at Single Clone Resolution, Mark Dawson
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Alejandro Gutierrez, MD: Associate Professor, Boston Children's Hospital, MA
Britta Will, PhD: Associate Professor, Albert Einstein College of Medicine, Bronx, NY
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Moderators: Britta Will and Alejandro Gutierrez
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Therapeutic Targeting of SF3B1-Mutant Stem Cells
March 04, 2024
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Moderators: Julie Thoms and Sergei Doulatov
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Targeting Aberrant Gene Control in Leukemias
March 04, 2024 -
Targeting Bcl-XL in Leukemias
March 04, 2024 -
DYRK1A Regulates Alternative Splicing in B-ALL
March 04, 2024
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Moderators: Marina Konopleva and Vincent Rondeau
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RNA Regulators and Control of Cell Fate
March 04, 2024 -
Stem Cells in Human AML
March 04, 2024
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Moderators: Pilar Dominguez and Stavroula Kousteni
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Moderators: Advaitha Madireddy and Paresh Vyas
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Moderators: Lev Silverstein and Dan Tenen
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Evil Enhancers in AML
March 04, 2024
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Moderators: Kim Stegmaier and Andrew Volk
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Epigenetic Basis and Therapy of DLBCL
March 04, 2024
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Moderators: Britta Will and Alejandro Gutierrez
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