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Protein Phosphatases - 2024, Student Price
$150.00
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Protein Phosphatases - 2024, Non-Conference Attendee Price
$300.00
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10.1096/PP2024
Protein Phosphatases - 2024 (Conferences On-Demand)
December 08, 2024 - December 12, 2024
This year’s conference is our second year in direct collaboration with the Japanese Association for Protein Phosphatase Research (JAPPR) conference and will continue to provide a foundation in the discipline to early-career investigators and inform experienced researchers of new developments. For nearly 35 years, this conference has explored the roles of protein phosphatases in normal physiology and pathological conditions. This is the only event in North America that provides this opportunity and is essential to supporting growth within this field of research. Sessions during this meeting will apply to a variety of audiences, including basic, translational, and clinical researchers from across academia and industry. Protein phosphatases are involved in virtually every area of cellular biology. As researchers across multiple disciplines decipher the complexities of a particular signaling pathway, the essential regulatory role of protein phosphatases repeatedly emerges, driving more scientists to study these enzymes. This conference will cover the spectrum of research from basic science to potentially new targets for disease therapeutics.
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December 8, 2024
Session 1: Cardiovascular
- Developmental Defects in Zebrafish Rasopathy Models, Jeroen den Hertog
- Phospho-regulation of Liprin-α1liquid-liquid Phase Separation by the Interacting PPP2R5D-PP2A Holoenzyme Is Impaired by Expression of Apathogenic HJS1 p.E420K Variant, Abigail Mayer
These presenters have opted out of being recorded:
- The Effect of Nicotine on the Adolescent Heart and Brain, Nicole Purcell
- Signaling by SHP2 in Cardiovascular Disease, Anton Bennett
Keynote: Rising Star
- CD47 Promotes Peripheral T Cell Survival by Preventing Dendritic Cell-Mediated T Cell Necroptosis, Satomi Komori
This presenter has opted out of being recorded:
- T Cell Specific SHP2 Deletion Prevents Pathology in a Systemic Lupus Erythematosus Mouse Model Via Modulation of the T Cell Receptor Signaling Pathway, Samantha Le Sommer
December 9, 2024
Session 2: Cancer
- From Mutations to Small Molecules: Lessons Learned from Protein Phosphatase, Heide Ford
- Exploring Allosteric Inhibitors of the SHP2 Protein Tyrosine Phosphatases Through High Throughput Screening, Masanori Hatakeyama
- The Dual Functions of Phosphatase of Regenerating Liver-3 (PRL-3) in Development and Cancer, Jessi Blackburn
- The Roles of pp2a Inhibitory Proteins in Cancer, Takashi Ohama
- Eya3/PP2A and the Pre Metastatic Niche in Triple Negative Breast Cancer, Heide Ford
- Novel Role for pp2a-b56 in egfr Signaling in Pancreatic Cancer, Claire Pfeffer
Session 3: Biochemistry
- Deciphering the Etiology of ppp2r5d-Related Intellectual Disability (Jordan’s Syndrome), Richard Honkanen
- Structural Genetics to Understand Holoenzyme Biogenesis, Assembly, and Substrate Selection of PP2A Phosphatases, Derek Taylor
- Translation of Electrical Signal into Chemical Signal by Voltage-sensing Phosphoinositide Phosphatase, VSP; How and Why? Yasushi Okamura
- PP2A-B55 – Regulation and Substrate Recognition, Jakob Nilsson
- Regulation of the Cytoskeleton by Mitochondrial Protein Phosphatase pgam5 During Mitophagy, Susumu Tanimura
- Regulation and Functional Implications of Nuclear pka/phosphatase Equilibrium, Konstantinos Lefkimmiatis
Session 4: Cancer
- New Tricks by Old PTPs, Benjamin Neel
- Mutant ppp2r1a Cells Secrete igfbp2 to Promote High-Grade Uterine Cancer Tumorigenesis, Irene Peris Martinez
This presenter has opted out of being recorded:
- Phosphoproteogenomics Analysis of Species-Specific Cellular Transformation Mechanisms, Jukka Westermarck
Session 5: Metabolism
- Metabolic Cell Reprogramming in Obesity-Associated Liver Cancer, Esteban N. Gurzov
- SIRPα Mediates Insulin/IGF1 Receptor in Chronic Kidney Disease Induced-Cardiomyopathy, Sandhya Thomas
These presenters have opted out of being recorded:
- Targeting Protein Tyrosine Phosphatase 1B (PTP1B) in Cardiometabolic Disease, Mirela Delibegovic
- DUSP22 and LYZ Cooperatively Induce FASN Lysosomal Degradation and Prevent Obesity, Huai-Chia Chuang
December 10, 2024
Session 6: Therapeutics
- Complex Roles of PTPN11/SHP2 in Carcinogenesis and Prospect of Targeting SHP2 in Cancer Therapy, Gen-Sheng Feng
- Uncovering Novel Regulators of Protein Phosphatase 2A-like Ser/Thr Protein Phosphatases Through Genome Wide Knockout and Base Editing Screens, Bob Meeusen
These presenters have opted out of being recorded:
- Functional Analysis of Membrane-Permeable DNA Aptamers Targeting Intracellular ser/thr Protein Phosphatase, Yoshiro Chuman
- Exploring the Therapeutic Potential of Targeting Phosphoglycolate Phosphatase, Antje Gohla
- Therapeutic Potential of Targeting the Sirp Family in Cancer Immunotherapy, Yoji Murata
- Development of Allosteric Inhibitors of Oncogenic Phosphatases in Cancer Signaling Pathways, Joe Lewis
Session 7: Immune
- Interaction Between PTPN2 Loss of Function and Rheumatoid Arthritis Patient Microbiome Promotes Arthritis in skg Mice, Sho Sendo
- Regulation of Autoimmune Responses in Lupus by the SHP-1-Activating Inhibitory B Cell Receptor cd72, Takeshi Tsubata
- Mapping the Substrates of Classical Protein Tyrosine Phosphatases with Photo-Crosslinking Chemistry, Andrew Johns
These presenters have opted out of being recorded:
- Targeting PTPRS for lupus nephritis, Nunzio Bottini
- Myeloid-Specific Regulation of RhoA in Cardiac Fibrosis, Maria Kontaridis
- Discovering Small Molecule Inhibitors of a Novel Dual Specificity Phosphatase to Treat Inflammatory Bowel Disease, Natalia Ogrodnik
Session 8: Signaling
- DUSPs in T-cell Signaling and Inflammation, Tse-Hua Tan
- The Dynamics of Pseudophosphatase MK-STYX as a Signaling Molecule in Neuronal Models, Shantá D. Hinton
- PPP3CA Neurodevelopmental Disorder-Associated Calcineurin Variants Disrupt Synaptic Signaling Pathways, Tom Cast
These presenters have opted out of being recorded:
- Disorders of Sex Development in Mice Lacking Phosphoinositide-Metabolizing Phosphatases, Takeshi Tsubata
- Phantom Phosphorylation in Eukaryotic Transcription, Jessie Zhang
Session 9: Signaling
- Protein Phosphatase 1 (PP1) Is Essential for Accurate Progression Through Mouse Oocyte Meiosis, Nikki Camlin
- Phosphate as a Safety Switch: Control of Protein Kinase C by the PH Domain Leucine Rich Repeat Phosphatase PHLPP, Alexandra Newton
- Discovering New Signaling Pathways Regulated by ca2+ and Calcineurin, Martha S. Cyert
- Rap1GAP Is Regulated by Calcineurin in Acute Pancreatitis, Sneha Roy
These presenters have opted out of being recorded:
- Lessons from the Calcineurin Knockout Fission Yeast: the Broad Contribution of Calcineurin in Cellular Homeostasis and Cell Survival, Teruki Takasaki
- Reprogramming the Equilibrium Between ON and OFF, Jui-Hsia Weng
December 11, 2024
Session 10: Cancer
- Using the Cancer Dependency Map, William C. Hahn
- Sequence Space Exploration in a Tyrosine Phosphatase, Neel Shah
- Amelioration of Acute Lung Injury with a Protein Tyrosine Phosphatase, Elizabeth R. Sharlow
These presenters have opted out of being recorded:
- Inhibition of ser/thr Phosphatase ppm1d Induces Alternative Splice Variant of ceacam3 in Neutrophils, Rui Kamada
- New Insights into pp2a-Related Houge-janssens Syndrome from Model Systems and Biochemical Studies, Veerle Janssens
- Regulation of Non-Small Cell Lung Cancer (NSCLC) Cellular Plasticity and EMT by PP2A, Brittany Allen-Petersen
Session 11: Biochemistry
- Molecular and Structural Basis for Nuclear Translocation of PTPN2/TCPTP by Cargo Proteins Importin-β1 and Importin-α5, Tzu-Ching Meng
These presenters have opted out of being recorded:
- Phosphatase Influence of Cardiac Remodeling and Dysfunction, Kate Weeks
- A Tale of Two Domains: Uncovering Endogenous Allostery in Double-Domain rptps, Lalima Madan
- Cardiomyocyte-Specific Deletion of ptp1b Protects Against hfd-Induced Cardiomyopathy Through Direct Regulation of Cardiac Metabolic Signaling, Abhishek Mishra
- PTP1B and TCPTP: Double Agents in Cancer and Metabolism, Tony Tiganis
Session 12: Therapeutics
- Haploinsufficiency of the PPP2R1A Tumor Suppressor Gene Promotes Spontaneous Mammary Tumorigenesis, Caitlin O’Connor
- Therapeutic Targeting of Protein Tyrosine Phosphatases, Zhong-Yin Zhang
- Investigating Phosphoprotein Phosphatase Signaling Using a Targeting Peptide, Arminja Kettenbach
- Dietary Pro-oxidant Therapy and Cell Death by Triaptosis, Lloyd Trotman
- Characterizing Disease Associated SHP2 Mutations from the Molecular to the Systems Level, Anne van Vlimmeren
This presenter has opted out of being recorded:
- PTP1B Inhibition – a Clinic-Ready, Mechanism-Based Approach to the Treatment of Rett Syndrome, Brittany Allen-Peterson
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Brittany Allen-Petersen, PhD: Assistant Professor, Purdue University, West Lafayette, IN
Yoshiro Chuman, PhD: Research Professor, Department of Chemistry, Niigata University, Niigata, Japan
Maria Kontaridis, PhD: Executive Director
Gordon K. Moe Professor and Chair of Biomedical Research and Translational Medicine, Director of Research, Masonic Medical Research Institute, Associate Professor of Medicine, Harvard Medical School, Cambridge, MA
Hiroshi Ohnishi, PhD: Professor, Gunma University Graduate School of Health Sciences, Gunma, Japan
Rosalie Sears, PhD: Professor, Oregon Health & Science University, Portland, OR
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Chair: Nicole Purcell
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Developmental Defects in Zebrafish Rasopathy Models
January 06, 2025
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Chair: Rosalie Sears
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Chair: Heide Ford
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The Roles of PP2A Inhibitory Proteins in Cancer
January 06, 2025
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Chair: Antje Gohla
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PP2A-B55 – Regulation and Substrate Recognition
January 06, 2025
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Chair: Martha Cyert
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New Tricks by Old PTPs
January 06, 2025
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Chair: Lloyd Trotman
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Chair: Goutham Narla
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Chair: Benjamin Neel
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Chair: Takeshi Tsubata
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DUSPs in T-cell Signaling and Inflammation
January 06, 2025
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Chair: Anton Bennett
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Rap1GAP Is Regulated by Calcineurin in Acute Pancreatitis
January 06, 2025
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Chair: Arminja Kettenbach
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Using the Cancer Dependency Map
January 06, 2025 -
Sequence Space Exploration in a Tyrosine Phosphatase
January 06, 2025
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Chair: Shantá D. Hinton
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Chair: Brittany Allen-Petersen
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Haploinsufficiency of the PPP2R1A Tumor
January 06, 2025 -
Therapeutic Targeting of Protein Tyrosine Phosphatases
January 06, 2025 -
Dietary Pro-oxidant Therapy and Cell Death by Triaptosis
January 06, 2025
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